200 CYTOKINES DOWNREGULATE NPPl AND THEREFORE INDUCE CARTILAGE MINERALIZATION IN OA

Cartilage Extracellular Matrix Integrity and OA

Annexins - their role in cartilage mineralization.

Annexins II, V and VI are highly expressed by hypertrophic and terminally differentiated growth plate chondrocytes and by osteoblasts. Because of the localization of annexins in areas of cartilage and bone mineralization, we hypothesized that these annexins play a regulatory role in the mineralization process. In this article we review the function of annexins II, V and VI in physiological mine...

Antiviral Cytokines Induce Hepatic

Interactions between subchondral bone and cartilage in OA. Cells from osteoarthritic bone can alter cartilage metabolism.

Osteoarthritis and cartilage: the role of cytokines.

The pathogenesis of osteoarthritis involves multiple etiologies, including mechanical, biochemical, and genetic factors that contribute to the imbalance in the synthesis and destruction of articular cartilage. It is now well documented that interleukin-1 and tumor necrosis factor-alpha are the predominant proinflammatory and catabolic cytokines involved in disease initiation and progression. Ot...